{"id":3504,"date":"2019-07-07T17:05:22","date_gmt":"2019-07-07T15:05:22","guid":{"rendered":"http:\/\/www.nanosilicaldevices.com\/home-page-2\/"},"modified":"2021-03-31T17:52:59","modified_gmt":"2021-03-31T15:52:59","slug":"home-page-2","status":"publish","type":"page","link":"http:\/\/www.nanosilicaldevices.com\/it\/","title":{"rendered":"Home Page"},"content":{"rendered":"<p>[vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;fullwidth&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;false&#8221; rt_bg_effect=&#8221;classic&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_video_format=&#8221;self-hosted&#8221;][vc_column rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div id=\"content-slider-538678\" class=\"rt-carousel main-carousel carousel-holder clearfix\" data-item-width=\"1\" data-mobile-height=\"380\" data-nav=\"true\" data-dots=\"true\" data-parallax=\"false\" data-timeout=\"10000\" data-autoplay=\"true\">\n<div class=\"owl-carousel\">\n\n\t\t<div class=\"item  alt-style-2\" style=\"background-image: url(http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2017\/11\/slider_blood_1920.jpg);background-repeat: no-repeat;background-size: cover;background-position: center center;min-height: 580px;\">\n\t\t\t<a href=\"#\" target=\"_self\" title=\"\"><\/a>\n\t\t\t<div class=\"slide-content-wrapper default clearfix\">\n\t\t\t\t<div class=\"slide-content  left text-left\" style=\"width: 45%;margin-top: 210px;\" data-mobile-top-margin= \"80\">\t\t\t\n\t\t\t\t\t<h2 class=\"slide_heading\" style=\"font-size:52px; line-height:110%\" data-mobile-value=\"28\" data-mobile-line-height=\"150%\">I NOSTRI SISTEMI<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"title-line\"><\/div><div class=\"slide-text\"><p>Produciamo micro e nanosistemi di silici mesoporose multifunzionali intelligenti finalizzati alla terapia farmacologica mirata<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-1\"><a  href=\"\/it\/i-nostri-sistemi\/\" target=\"_self\" title=\"SCOPRI\" class=\"button_  color small\">SCOPRI<\/a><\/div>\n\t\t\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-2\"><a  href=\"\/it\/pubblicazioni-proprieta-intellettuale\/\" target=\"_self\" title=\"BREVETTI\" class=\"button_  white small\">BREVETTI<\/a><\/div>\n\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"item  alt-style-2\" style=\"background-image: url(http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2018\/11\/smau_award.jpg);background-repeat: no-repeat;background-size: cover;background-position: right top;background-color: rgba(147,147,147,0.5);min-height: 580px;\">\n\t\t\t\n\t\t\t<div class=\"slide-content-wrapper default clearfix\">\n\t\t\t\t<div class=\"slide-content  left text-left\" style=\"width: 60%;margin-top: 210px;\">\t\t\t\n\t\t\t\t\t<h2 class=\"slide_heading\" style=\"font-size:52px; line-height:110%\" data-mobile-value=\"28\" data-mobile-line-height=\"1.5\">Premio Innovazione SMAU alla NanoSiliCal Devices S.r.l.<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"title-line\"><\/div><div class=\"slide-text\"><p>Esempio virtuoso nell\u2019adottare soluzioni innovative che hanno migliorato le performance del proprio business, la NanoSiliCal Devices continua ad accumulare riconoscimenti tra i quali il Premio Innovazione SMAU<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-1\"><a  href=\"\/it\/premio-innovazione-smau-alla-nanosilical-devices-s-r-l\/\" target=\"_self\" title=\"DIMMI DI PI\u00d9\" class=\"button_  color medium\"><span class=\"icon-doc-1\"><\/span>DIMMI DI PI\u00d9<\/a><\/div>\n\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"item  alt-style-2\" style=\"background-image: url(http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2017\/11\/westbay-2337262_1920.jpg);background-repeat: no-repeat;background-size: cover;background-position: center center;min-height: 580px;\">\n\t\t\t\n\t\t\t<div class=\"slide-content-wrapper default clearfix\">\n\t\t\t\t<div class=\"slide-content  left text-left\" style=\"width: 70%;margin-top: 220px;\" data-mobile-top-margin= \"80\">\t\t\t\n\t\t\t\t\t<h2 class=\"slide_heading\" style=\"font-size:42px;\" data-mobile-value=\"28\" data-mobile-line-height=\"1.5\">NANOSILICAL SCELTA DAGLI INVESTITORI INTERNAZIONALI<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"title-line\"><\/div><div class=\"slide-text\"><p>Nell&#8217;Aprile 2017, NanoSiliCal Devices ha firmato un accordo di partnership strategica con il sig. Mohammed A. Al Emadi, componente di una importante famiglia del Qatar, che diventa cos\u00ec il primo investitore straniero.<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-1\"><a  href=\"\/it\/nanosilical-devices-il-ponte-unical-arriva-in-qatar\/\" target=\"_self\" title=\"LEGGI\" class=\"button_  color small\">LEGGI<\/a><\/div>\n\t\t\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-2\"><a  href=\"\/it\/mercato\/\" target=\"_self\" title=\"INVESTITORI\" class=\"button_  white small\">INVESTITORI<\/a><\/div>\n\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"item  alt-style-2\" style=\"background-image: url(http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2017\/11\/chemical_formula.jpg);background-repeat: no-repeat;background-size: cover;background-position: center center;min-height: 580px;\">\n\t\t\t\n\t\t\t<div class=\"slide-content-wrapper default clearfix\">\n\t\t\t\t<div class=\"slide-content  left text-left\" style=\"width: 45%;margin-top: 220px;\" data-mobile-top-margin= \"80\">\t\t\t\n\t\t\t\t\t<h2 class=\"slide_heading\" style=\"font-size:46px; line-height:130%\" data-mobile-value=\"28\" data-mobile-line-height=\"150%\">PERCH\u00c9 I NOSTRI SISTEMI<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"title-line\"><\/div><div class=\"slide-text\"><p>Efficacia terapeutica associata ad una drastica riduzione della tossicit\u00e0 e degli effetti collaterali<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-1\"><a  href=\"\/it\/vantaggi-dei-nostri-sistemi\/\" target=\"_self\" title=\"I VANTAGGI\" class=\"button_  color small\">I VANTAGGI<\/a><\/div>\n\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"item  alt-style-2\" style=\"background-image: url(http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2017\/11\/markets_1920.png);background-repeat: no-repeat;background-size: cover;background-position: center center;min-height: 580px;\">\n\t\t\t\n\t\t\t<div class=\"slide-content-wrapper default clearfix\">\n\t\t\t\t<div class=\"slide-content  left text-left\" style=\"width: 70%;margin-top: 220px;\" data-mobile-top-margin= \"80\">\t\t\t\n\t\t\t\t\t<h2 class=\"slide_heading\" style=\"font-size:42px;\" data-mobile-value=\"28\" data-mobile-line-height=\"1.5\">MERCATO IN RAPIDA ESPANSIONE<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"title-line\"><\/div><div class=\"slide-text\"><p>Il mercato dei sistemi di drug delivery crescer\u00e0 dagli 11,3 miliardi di dollari del 2012 a 30,9 miliardi nel 2017<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t<div class=\"button_wrapper align button-1\"><a  href=\"\/it\/mercato\/\" target=\"_self\" title=\"LEGGI\" class=\"button_  color small\">LEGGI<\/a><\/div>\n\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div><\/div>\n\n\t\t\t\t<div id=\"content-slider-538678-dots\" class=\"dots-holder\">\n\t\t\t\t<\/div>\n\t\t\t\n<\/div>\n[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;parallax&#8221; rt_bg_parallax_effect=&#8221;1&#8243; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_row_width=&#8221;default&#8221; rt_row_placement=&#8221;true&#8221; rt_grid=&#8221;&#8221; rt_padding_top=&#8221;60&#8243; rt_padding_bottom=&#8221;60&#8243;][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">01<\/span>PERCH\u00c9 I NOSTRI SISTEMI<\/h4>\n\t\t\t\t\t<\/div>[vc_column_text]Le micro-nanoparticelle di silice mesoporosa sono le candidate ideali per lo sviluppo di sistemi per il direzionamento di farmaci, in quanto di facile sintesi, versatili, biocompatibili e sospendibili nei fluidi biologici.[\/vc_column_text][vc_empty_space height=&#8221;5px&#8221;]<a  href=\"\/it\/vantaggi-dei-nostri-sistemi\/\" target=\"_self\" title=\"Link Title\" class=\"read_more class name text small align\">Informazioni<\/a>[\/vc_column][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">02<\/span>PERCH\u00c9 NOI<\/h4>\n\t\t\t\t\t<\/div>[vc_column_text]La NanoSiliCal Devices \u00e8 uno spin off dell\u2019Universit\u00e0 della Calabria ed una start-up innovativa, fondata nel 2014 e finalizzata allo sviluppo di prodotti nano-strutturati in grado di rendere intelligenti le terapie antitumorali.[\/vc_column_text][vc_empty_space height=&#8221;5px&#8221;]<a  href=\"\/it\/chi-siamo\/\" target=\"_self\" title=\"Link Title\" class=\"read_more class name text small align\">Leggi<\/a>[\/vc_column][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">03<\/span>INVESTITORI<\/h4>\n\t\t\t\t\t<\/div>[vc_column_text]Il mercato delle biotecnologie \u00e8 uno dei settori che sperimenta i pi\u00f9 ampi fattori di crescita ed \u00e8 destinato ad espandersi ulteriormente nei prossimi anni. NanoSiliCal Devices, per l&#8217;alto fattore di innovazione dei suoi prodotti, rappresenta una importante opportunit\u00e0 di investimento.[\/vc_column_text][vc_empty_space height=&#8221;5px&#8221;]<a  href=\"\/it\/mercato\/\" target=\"_self\" title=\"Link Title\" class=\"read_more class name text small align\">Di pi\u00f9<\/a>[\/vc_column][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">04<\/span>LABORATORI<\/h4>\n\t\t\t\t\t<\/div>[vc_column_text]I laboratori di NanoSiliCal Devices sono ospitati, insieme con altri, nell&#8217;area del Dipartimento di Farmacia e Medicina e Scienze Nutrizionali, un dipartimento ideale per i trasferimenti di tecnologia.[\/vc_column_text][vc_empty_space height=&#8221;5px&#8221;]<a  href=\"\/it\/i-laboratori\/\" target=\"_self\" title=\"Link Title\" class=\"read_more class name text small align\">Vai ai laboratori<\/a>[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;alt-style-1&#8243; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;top,bottom&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;parallax&#8221; rt_bg_parallax_effect=&#8221;3&#8243; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_grid=&#8221;true&#8221; rt_padding_top=&#8221;90&#8243; rt_padding_bottom=&#8221;90&#8243; rt_video_overlay_color=&#8221;rgba(239,239,239,0.92)&#8221; rt_bg_video_mp4=&#8221;2362&#8243; rt_bg_overlay_color=&#8221;rgba(245,245,245,0.94)&#8221;][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_padding_top=&#8221;50&#8243; rt_padding_bottom=&#8221;50&#8243; rt_bg_color=&#8221;&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">Che cosa ci rende cos\u00ec speciali<\/span>I NOSTRI PRODOTTI<\/h4>\n\t\t\t\t\t<\/div>[vc_column_text]La tecnologia dei nostri prodotti si basa sulla scienza dei materiali, che consente lo sviluppo di particelle nanostrutturate che possono essere somministrate per via endovenosa e, attraverso il flusso sanguigno, possono raggiungere le cellule tumorali, interagire con esse attraverso un processo biologico e rilasciare il farmaco al loro interno. Ci\u00f2 garantisce una riduzione delle dosi terapeutiche e degli effetti collaterali con un conseguente miglioramento dell&#8217;efficacia terapeutica.[\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;]<div class=\"button_wrapper align \"><a  href=\"\/it\/prodotti\/\" target=\"_self\" title=\"DIMMI DI PI\u00d9\" class=\"button_  color small\">DIMMI DI PI\u00d9<\/a><\/div>[\/vc_column][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_padding_top=&#8221;50&#8243; rt_padding_bottom=&#8221;50&#8243; rt_padding_left=&#8221;0&#8243; rt_padding_right=&#8221;0&#8243; rt_bg_color=&#8221;rgba(0,0,0,0.03)&#8221; offset=&#8221;vc_col-md-3 vc_col-xs-6&#8243; rt_bg_overlay_color=&#8221;&#8221;]<div  class=\"rt_counter\"><span class=\"number\">15<\/span>ricercatori<\/div>[vc_empty_space height=&#8221;30px&#8221;]<div  class=\"rt_counter\"><span class=\"number\">10<\/span>anni di esperienza<\/div>[\/vc_column][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_padding_top=&#8221;50&#8243; rt_padding_bottom=&#8221;50&#8243; rt_padding_left=&#8221;0&#8243; rt_padding_right=&#8221;0&#8243; rt_bg_color=&#8221;rgba(0,0,0,0.03)&#8221; offset=&#8221;vc_col-md-3 vc_col-xs-6&#8243; rt_bg_overlay_color=&#8221;&#8221;]<div  class=\"rt_counter\"><span class=\"number\">2<\/span>brevetti rilasciati<\/div>[vc_empty_space height=&#8221;30px&#8221;]<div  class=\"rt_counter\"><span class=\"number\">5<\/span>progetti finanziati (EU e regionali)<\/div>[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;classic&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_grid=&#8221;true&#8221; rt_padding_top=&#8221;80&#8243; rt_padding_bottom=&#8221;40&#8243;][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<article  class=\"icon-content-box content-box icon-left icon-style-2\"><div class=\"icon-holder\"><span class=\"icon-doc-alt\"><\/span><\/div><div class=\"text-holder\"><h5 class=\"heading\">MSNs veicolanti un pro-farmaco ed una funzione targeting<\/h5> <p>Micro o nanosistemi di silici mesoporose finalizzati alla terapia mirata in quanto provvisti di una funzione direzionante e di un farmaco coniugato alla superficie dei pori delle MSNs attraverso un legame pH-sensibile, stabile in ambiente neutro e labile nell\u2019ambiente intracellulare, consentendo il trasporto del farmaco in una forma biologicamente inattiva (pro-farmaco) attraverso il torrente ematico, fino al raggiungimento del tessuto bersaglio, dove si ha il rilascio della forma attiva del farmaco.<\/p>\n<\/div><\/article>[\/vc_column][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<article  class=\"icon-content-box content-box icon-left icon-style-2\"><div class=\"icon-holder\"><span class=\"he icon-doc-alt icon-new-heart-1\"><\/span><\/div><div class=\"text-holder\"><h5 class=\"heading\">MSNs per il drug targeting con sistema avidina-biotina<\/h5> <p>Micro o nanosistemi di silici mesoporose provvisti di una funzione direzionante altamente specifica (ad es., un anticorpo monoclonale, rivolto contro un marker tumorale, legato alla biotina, a sua volta ancorata alle MSNs mediante l\u2019avidina). Il sistema, coniugato al farmaco con rilascio pH sensibile, \u00e8 capace di promuovere l\u2019internalizzazione ligando-mediata da parte delle cellule, determinandone la morte.<\/p>\n<\/div><\/article>[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;classic&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_grid=&#8221;true&#8221; rt_padding_top=&#8221;80&#8243; rt_padding_bottom=&#8221;40&#8243;][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<article  class=\"icon-content-box content-box icon-left icon-style-2\"><div class=\"icon-holder\"><span class=\"icon-doc-alt\"><\/span><\/div><div class=\"text-holder\"><h5 class=\"heading\">MSNs fluorescenti per diagnostica per immagini<\/h5> <p>Micro o nanosistemi di silici mesoporose provvisti di una funzione direzionante altamente specifica e un marcatore fluorescente che consenta la individuazione visiva delle cellule target.<\/p>\n<\/div><\/article>[\/vc_column][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<article  class=\"icon-content-box content-box icon-left icon-style-2\"><div class=\"icon-holder\"><span class=\"icon-doc-alt\"><\/span><\/div><div class=\"text-holder\"><h5 class=\"heading\">MSNs complessate con DNA plasmidico<\/h5> <p>Micro o nanosistemi di silici mesoporose provvisti di una funzione direzionante altamente specifica e porosit\u00e0 di diametro adeguato all\u2019inclusione del DNA plasmidico codificante per proteine che si desidera esprimere in un dato sistema cellulare (ricerca sperimentale di base), oppure in uno specifico organismo, nel caso di deficit responsabile di una determinata patologia (terapia genica).<\/p>\n<\/div><\/article>[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;alt-style-1&#8243; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;top,bottom&#8221; rt_column_view=&#8221;boxed_columns&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;classic&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_grid=&#8221;&#8221; rt_padding_top=&#8221;40&#8243; rt_padding_bottom=&#8221;40&#8243;][vc_column width=&#8221;1\/3&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_holder=&#8221;wrapper&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_color=&#8221;&#8221;]\n\t\t\t\t<article  class=\"image-content-box content-box box-style-2 left\"> \n\t\t\t\t\t<div class=\"background\" style=\"background:url(http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2016\/01\/box-1.jpg) no-repeat scroll center center \/ cover ;\">\n\t\t\t\t\t\t<div class=\"text-holder\" style=\"color:#000000\">\n\t\t\t\t\t\t\t\n\t<h4 class=\"heading\" style=\"color:#000000\">\n\t\t<a href=\"\/it\/chi-siamo\/\" title=\"Il nostro team\" target=\"_self\" style=\"color:#000000\">\n\t\t\tIl nostro team\n\t\t<\/a>\n\t<\/h4> <p>Il nostro team \u00e8 composto da professionisti altamente qualificati con molti anni di esperienza e formazione nei rispettivi ambiti, autori di molte pubblicazioni e che possono vantare numerose collaborazioni con istituzioni di prestigio. Scopri di pi\u00f9 sul nostro team consultando l&#8217;apposita sezione.<\/p>\n <a class=\"read_more\" href=\"\/it\/chi-siamo\/\" title=\"fai click qui\" target=\"_self\" style=\"color:#000000\">fai click qui<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"mask\" style=\"background-color:rgba(234,234,234,0.85)\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t[\/vc_column][vc_column width=&#8221;1\/3&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<article  class=\"image-content-box content-box box-style-1 left no-featured-image\"><div class=\"text-holder\"> <div class=\"video-container\"><iframe loading=\"lazy\" title=\"Presentazione dell&#039;azienda da parte del CEO\" width=\"1060\" height=\"596\" src=\"https:\/\/www.youtube.com\/embed\/8e4usDcTRDk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n<div style=\"maring-top: 20px;\">\n<p>Il Prof. Luigi Pasqua, CEO di NanoSiliCal Devices, spiega la ricerca e gli sviluppi innobativi delle attivit\u00e0 della nostra azienda.<\/p>\n<\/div>\n<\/div><\/article>[\/vc_column][vc_column width=&#8221;1\/3&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<article  class=\"image-content-box content-box box-style-1 left no-featured-image\"><div class=\"text-holder\"><h4 class=\"heading\">Partner spotlight<\/h4> <p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-3478\" src=\"\/wp-content\/uploads\/2019\/03\/ensymm_logo_new.jpg\" alt=\"\" width=\"561\" height=\"223\" srcset=\"http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2019\/03\/ensymm_logo_new.jpg 561w, http:\/\/www.nanosilicaldevices.com\/wp-content\/uploads\/2019\/03\/ensymm_logo_new-300x119.jpg 300w\" sizes=\"auto, (max-width: 561px) 100vw, 561px\" \/><\/p>\n<p>Nel 2017, <strong>Ensymm<\/strong> ha gestito l&#8217;investimento dello sceicco Mohammed Alemadi del Qatar in NanoSiliCal Devices. Da allora, Ensymm \u00e8 entrata in una partnership strategica con NanoSiliCal Devices per generare ulteriori opportunit\u00e0 di investimento per sostenere i progressi nella ricerca e sviluppo con l&#8217;obbiettivo di diventare una delle aziende leader nel settore biotech come sviluppatore di nanosistemi basati sul silicio per la somministrazione di farmaci.<\/p>\n<\/div><\/article>[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;classic&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_row_width=&#8221;default&#8221; rt_padding_top=&#8221;50&#8243; rt_padding_bottom=&#8221;50&#8243; rt_grid=&#8221;&#8221;][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">dal nostro blog<\/span>NOVIT\u00c0<\/h4>\n\t\t\t\t\t<\/div>[vc_separator style=&#8221;style-4&#8243; margin_top=&#8221;0&#8243; margin_bottom=&#8221;30&#8243;]<div class=\"latest_news clearfix style-1\"><article>\n\n\t\t\t\t\t<div class=\"date\">\n\t\t\t\t\t\t<span class=\"day\">14<\/span><span class=\"month\">Dic<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\n\t\t\t\t\t<div class=\"text\">\n\t\t\t\t\t\t<h5 class=\"clean_heading\"><a class=\"title\" href=\"http:\/\/www.nanosilicaldevices.com\/it\/la-nanosilical-devices-vincitrice-dellincentivo-brevetti-gestito-da-invitalia\/\" title=\"La NanoSiliCal Devices vincitrice dell\u2019incentivo Brevetti + gestito da Invitalia.\" rel=\"bookmark\">La NanoSiliCal Devices vincitrice dell\u2019incentivo Brevetti + gestito da Invitalia.<\/a><\/h5>\n\t\t\t\t\t\t<p>Il 16 ottobre 2020 la NanoSiliCal Devices, PMI dell\u2019Universit\u00e0 della Calabria, viene riconosciuta vi...<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n<\/article>\n<article>\n\n\t\t\t\t\t<div class=\"date\">\n\t\t\t\t\t\t<span class=\"day\">22<\/span><span class=\"month\">Set<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\n\t\t\t\t\t<div class=\"text\">\n\t\t\t\t\t\t<h5 class=\"clean_heading\"><a class=\"title\" href=\"http:\/\/www.nanosilicaldevices.com\/it\/premio-sulla-buona-stradacalabresi-d-o-p-a-nanosilical-devices\/\" title=\"Premio \u201cSulla Buona Strada\u2026Calabresi D.O.P\u201d a NanoSiliCal Devices\" rel=\"bookmark\">Premio \u201cSulla Buona Strada\u2026Calabresi D.O.P\u201d a NanoSiliCal Devices<\/a><\/h5>\n\t\t\t\t\t\t<p>Nel corso della 4\u00b0 edizione del Premio \u201cSulla Buona Strada\u2026Calabresi D.O.P.\u201d, conferito dall\u2019Associa...<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n<\/article>\n<article>\n\n\t\t\t\t\t<div class=\"date\">\n\t\t\t\t\t\t<span class=\"day\">23<\/span><span class=\"month\">Ott<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\n\t\t\t\t\t<div class=\"text\">\n\t\t\t\t\t\t<h5 class=\"clean_heading\"><a class=\"title\" href=\"http:\/\/www.nanosilicaldevices.com\/it\/premio-innovazione-smau-alla-nanosilical-devices-s-r-l\/\" title=\"Premio Innovazione SMAU alla NanoSiliCal Devices S.r.l.\" rel=\"bookmark\">Premio Innovazione SMAU alla NanoSiliCal Devices S.r.l.<\/a><\/h5>\n\t\t\t\t\t\t<p>Esempio virtuoso nell\u2019adottare soluzioni innovative che hanno migliorato le performance del proprio...<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\n<\/article>\n<\/div>[\/vc_column][vc_column width=&#8221;1\/2&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-1\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-1\" ><span class=\"punchline\">perch\u00e8 dovresti scegliere NanoSiliCal Devices<\/span>CARATTERISTICHE DEI NOSTRI PRODOTTI<\/h4>\n\t\t\t\t\t<\/div>[vc_separator style=&#8221;style-4&#8243; margin_top=&#8221;0&#8243; margin_bottom=&#8221;30&#8243;]<div  class=\"rt-toggle \"><ol><li  class=\"open\"><div class=\"toggle-head\"><div class=\"toggle-number\">1<\/div><div class=\"toggle-title clean_heading\">Innovativi e brevettabili<\/div><\/div><div class=\"toggle-content\"><p>I nostri prodotti sono innovatibi e brevettabili. E&#8217; possibile acquisire licenze per i prossimi test clinici.<\/p>\n<\/div><\/li><li  class=\"\"><div class=\"toggle-head\"><div class=\"toggle-number\">2<\/div><div class=\"toggle-title clean_heading\">Biobetters<\/div><\/div><div class=\"toggle-content\"><p>Usando i nostri sistemi (i \u201cbiobetters\u201d) si incorre in un rischio di fallimento inferiore rispetto alle cosiddette entit\u00e0 chimiche.<\/p>\n<\/div><\/li><li  class=\"\"><div class=\"toggle-head\"><div class=\"toggle-number\">3<\/div><div class=\"toggle-title clean_heading\">Versatilit\u00e0<\/div><\/div><div class=\"toggle-content\"><p>Se paragonate alle altre tecnologie attualmente in uso (materiali polimerici, liposomi, nanosomi) gli MSN presentano una superficie interna ed esterna (pareti porose) con una alta reattivit\u00e0 che pu\u00f2 essere resa funzionale usando diverse molecole.<\/p>\n<\/div><\/li><li  class=\"\"><div class=\"toggle-head\"><div class=\"toggle-number\">4<\/div><div class=\"toggle-title clean_heading\">Processo di sintesi semplificato<\/div><\/div><div class=\"toggle-content\"><p>Il processo di sintesi \u00e8 semplificato, che \u00e8 ideale per incremento immediato di quantit\u00e0.<\/p>\n<\/div><\/li><li  class=\"\"><div class=\"toggle-head\"><div class=\"toggle-number\">5<\/div><div class=\"toggle-title clean_heading\">Nessuna interferenza<\/div><\/div><div class=\"toggle-content\"><p>Le particelle non interferiscono con gli agenti terapeutici associati alla superficie attiva.<\/p>\n<\/div><\/li><\/ol><\/div>[\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;alt-style-2&#8243; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;parallax&#8221; rt_bg_parallax_effect=&#8221;3&#8243; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_grid=&#8221;true&#8221; rt_padding_top=&#8221;120&#8243; rt_padding_bottom=&#8221;120&#8243; rt_bg_image=&#8221;2359&#8243; rt_video_overlay_color=&#8221;rgba(83,100,107,0.6)&#8221; rt_bg_overlay_color=&#8221;rgba(94,96,98,0.68)&#8221;][vc_column rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;]<div class=\"rt_heading_wrapper style-4\">\n\t\t\t\t\t\t<h4 class=\"rt_heading  with_punchline style-4\" ><span class=\"punchline\">MAGGIORI INFORMAZIONI SUI PARTNER DELLA NOSTRA AZIENDA<\/span>I NOSTRI PARTNER<\/h4>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<div id=\"slider-testimonial-dynamicID-915929\" class=\"rt-carousel carousel-holder clearfix testimonial-carousel testimonials center big\" data-item-width=\"1\" data-nav=\"true\" data-dots=\"false\" data-margin=\"40\" data-autoplay=\"false\" data-timeout=\"5000\" data-thumbnails=\"false\" data-boxed=\"false\">\r\n\t\t\t\t\t<div class=\"owl-carousel\">\r\n\t\t\t\t\t\t<div><div class=\"testimonial item\">\n\n\n\n<div class=\"text \">\n\t<p>\n\t\t<span class=\"icon-quote-left\"><\/span>\n\t\t\tEnsymm UG&amp;CO.KG is a German based premier project consulting company for Life Science, serving biotech companies, pharmaceutical industry and food ingredient companies. Ensymm offers technology transfer, project management and consulting for companies, governmental organization, private investors and universities. They provide clients with a variety of business and technology consulting services as well as with specialized teams in various areas of competence. \r\n\t\t<span class=\"icon-quote-right\"><\/span>\n\t<\/p>\n\t<div class=\"client_info\">\n\n\t\t\tEnsymm \n\t\t- <span>Project consulting company<\/span>\t\t\n\t\t<a href=\"http:\/\/ensymm.com\/\" target=\"_blank\" title=\"Visit Website\" class=\"client_link\">Visit Website<\/a>\t\t\t\n\t\t\n\n\t<\/div>\n<\/div><\/div>\n<\/div><div><div class=\"testimonial item\">\n\n\n\n<div class=\"text \">\n\t<p>\n\t\t<span class=\"icon-quote-left\"><\/span>\n\t\t\tL'Universit\u00e0 della Calabria (in breve UniCal) \u00e8 una universit\u00e0 statale italiana fondata nel 1972, la maggiore delle universit\u00e0 calabresi. L'Ateneo \u00e8 situato sulle colline di Arcavacata, frazione del comune di Rende, nell'area urbana di Cosenza. Tra i suoi fondatori vi furono Beniamino Andreatta, Giorgio Gagliani, Pietro Bucci e Paolo Sylos Labini. Nel 2016 si contano 27 672 studenti iscritti.\t\t<span class=\"icon-quote-right\"><\/span>\n\t<\/p>\n\t<div class=\"client_info\">\n\n\t\t\tUniversit\u00e0 della Calabria \n\t\t\t\t\n\t\t\t\t<a href=\"http:\/\/www.unical.it\" target=\"_blank\" class=\"client_link\">www.unical.it<\/a>\t\n\t\t\n\n\t<\/div>\n<\/div><\/div>\n<\/div><div><div class=\"testimonial item\">\n\n\n\n<div class=\"text \">\n\t<p>\n\t\t<span class=\"icon-quote-left\"><\/span>\n\t\t\tIl Fondo Europeo di Sviluppo Regionale (FESR) \u00e8 uno dei fondi strutturali dell'Unione europea. \u00c8 lo strumento principale della sua politica regionale ed \u00e8 gestito dal Commissario europeo per la Politica Regionale.\t\t<span class=\"icon-quote-right\"><\/span>\n\t<\/p>\n\t<div class=\"client_info\">\n\n\t\t\tFondo europeo di sviluppo regionale \n\t\t\t\t\n\t\t\t\t<a href=\"http:\/\/ec.europa.eu\/regional_policy\/index.cfm\/it\/funding\/erdf\/\" target=\"_blank\" class=\"client_link\">ec.europa.eu\/regional_policy\/index.cfm\/it\/funding\/erdf\/<\/a>\t\n\t\t\n\n\t<\/div>\n<\/div><\/div>\n<\/div><div><div class=\"testimonial item\">\n\n\n\n<div class=\"text \">\n\t<p>\n\t\t<span class=\"icon-quote-left\"><\/span>\n\t\t\tThe Patent Cooperation Treaty (PCT) assists applicants in seeking patent protection internationally for their inventions, helps patent Offices with their patent granting decisions, and facilitates public access to a wealth of technical information relating to those inventions. By filing one international patent application under the PCT, applicants can simultaneously seek protection for an invention in a very large number of countries.\t\t<span class=\"icon-quote-right\"><\/span>\n\t<\/p>\n\t<div class=\"client_info\">\n\n\t\t\tWIPO - PCT \n\t\t\t\t\n\t\t\t\t<a href=\"http:\/\/www.wipo.int\/pct\/en\/\" target=\"_blank\" class=\"client_link\">www.wipo.int\/pct\/en\/<\/a>\t\n\t\t\n\n\t<\/div>\n<\/div><\/div>\n<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t<\/div>\r\n\t\t\t[\/vc_column][\/vc_row][vc_column rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;][\/vc_column][vc_column rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;][\/vc_column]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;fullwidth&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;false&#8221; rt_bg_effect=&#8221;classic&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;cover&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_attachment=&#8221;scroll&#8221; rt_bg_video_format=&#8221;self-hosted&#8221;][vc_column rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;][\/vc_column][\/vc_row][vc_row rt_row_background_width=&#8221;fullwidth&#8221; rt_row_content_width=&#8221;default&#8221; rt_row_style=&#8221;default-style&#8221; rt_row_borders=&#8221;&#8221; rt_row_shadows=&#8221;&#8221; rt_row_paddings=&#8221;true&#8221; rt_bg_effect=&#8221;parallax&#8221; rt_bg_parallax_effect=&#8221;1&#8243; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_position=&#8221;right top&#8221; rt_bg_video_format=&#8221;self-hosted&#8221; rt_row_width=&#8221;default&#8221; rt_row_placement=&#8221;true&#8221; rt_grid=&#8221;&#8221; rt_padding_top=&#8221;60&#8243; rt_padding_bottom=&#8221;60&#8243;][vc_column width=&#8221;1\/4&#8243; rt_column_shadow=&#8221;&#8221; rt_bg_image_repeat=&#8221;repeat&#8221; rt_bg_size=&#8221;auto auto&#8221; rt_bg_attachment=&#8221;scroll&#8221;][vc_column_text]Le micro-nanoparticelle di silice mesoporosa sono le candidate ideali per lo sviluppo &#8230; <a class=\"more-link\" href=\"http:\/\/www.nanosilicaldevices.com\/it\/testimonial\/auto-draft-2\/\">Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3504","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/pages\/3504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/comments?post=3504"}],"version-history":[{"count":32,"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/pages\/3504\/revisions"}],"predecessor-version":[{"id":3866,"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/pages\/3504\/revisions\/3866"}],"wp:attachment":[{"href":"http:\/\/www.nanosilicaldevices.com\/it\/wp-json\/wp\/v2\/media?parent=3504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}